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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteroneenanthate. The subjects who lost the greatest number of kg during the study were also more likely to respond to a new, higher testosterone level during the following two years. The results showed that the weight loss programme was associated with a significant increase in testosterone and an increase in the rate at which men's levels increased. The effect of the new testosterone, which is of similar potency as the former one but has a lower bioactivity, was found to be most striking, not only in those taking lower doses of the male hormone but also in those taking higher doses.
The authors conclude that 'weight loss may help to alleviate the symptoms of depression'.
The researchers speculate that the effect results from testosterone acting both on the brain and body and reducing the release of cortisol during the periods of weight loss. Although they do not provide evidence of the link between weight loss and more severe psychological distress, the researchers say these preliminary findings are likely to be strengthened as more research is carried out.
Professor Martin Widerkerk of the Department of Psychology at Eindhoven University of Technology, the Netherlands, said: 'It could be that the 'stress relief' that comes with losing weight does a lot to ease the psychological effects of depression that many men suffering from depression struggle with. Perhaps the mechanism involves reducing stress hormones in the body and lowering cortisol levels resulting in greater overall depression and decreased motivation.'
Professor Widerkerk cautioned that the study did not directly measure whether testosterone was involved while the effect is potentially very important for future research. It was also possible that the increased testosterone level observed was being related to better compliance with the weight loss programme rather than any effect on depression.
Other researchers are now investigating whether testosterone levels could be reduced to mimic symptoms of depression and also look into which specific conditions testosterone may play a role in in the treatment of depression.
Dr Richard Gage, co-director of the Institute of Psychiatry, Psychology and Neuroscience at King's College London, said: 'The study adds further evidence to the suggestion of a key role for testosterone in the management of psychological suffering in the setting of weight loss. However, our research indicates that a greater focus on the importance of the hormone at the biological level, rather than the effects of the hormone on the behavioural side of treatment, will improve our ability to understand its role in depression and other psychological conditions.'
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